Article
The inflammation-associated Salmonella SopA is a HECT-like E3 ubiquitin ligase.
Molecular microbiology - 1 Nov 2006
Zhang Ying, Higashide Wendy M, McCormick Beth A, Chen Jue, Zhou Daoguo
Abstract excerpt
Salmonella translocate a group of type III effectors into the host cells to induce entry, promote survival and cause intestinal inflammation. Although the biochemical and cellular mechanisms of how bacterial effectors function inside host cells remain largely unknown, studies have indicated that a likely strategy is to exploit host cellular pathways through functional mimicry. We report here that SopA, a...
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