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Article

Active site tightness and substrate fit in DNA replication.

Annual review of biochemistry - 1 Jan 2002

Kool Eric T

Abstract excerpt

Various physicochemical factors influence DNA replication fidelity. Since it is now known that Watson-Crick hydrogen bonds are not necessary for efficient and selective replication of a base pair by DNA polymerase enzymes, a number of alternative physical factors have been examined to explain the efficiency of these enzymes. Among these factors are minor groove hydrogen bonding, base stacking, solvation, and...

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PMID: 12045095
DOI: 10.1146/annurev.biochem.71.110601.135453

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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