Article
Molecular responses to changes in the environmental pH are conserved between the fungal pathogens Candida dubliniensis and Candida albicans.
International journal of medical microbiology : IJMM - 1 Jul 2000
Heinz W J, Kurzai O, Brakhage A A, Fonzi W A, Korting H C, Frosch M, Mühlschlegel F A
Abstract excerpt
In this work we cloned CdPHR1 and CdPHR2 from the human fungal pathogen Candida dubliniensis. The two genes are homologues to the pH-regulated genes PHR1 and PHR2 from Candida albicans. The pH-dependent pattern of expression of CdPHR1 and CdPHR2 was conserved in C. dubliniensis. CdPHR1 could be shown to be functionally equivalent to PHR1. The pH-regulated mode of expression was maintained when CdPHR1 was...
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