Article
Identification of TNFRSF1B as a novel modifier gene in familial combined hyperlipidemia.
Human molecular genetics - 1 Sept 2000
Geurts J M, Janssen R G, van Greevenbroek M M, van der Kallen C J, Cantor R M, Bu X, Aouizerat B E, Allayee H, Rotter J I, de Bruin T W
Abstract excerpt
Familial combined hyperlipidemia (FCHL) is the most commonly inherited hyperlipidemia in man, with a frequency of +/-1% in the general population and approximately 10% in myocardial infarction survivors. A genomic scan in 18 Dutch FCHL families resulted in the identification of several loci with evidence for linkage. One of these regions, 1p36.2, contains TNFRSF1B which encodes one of the tumor necrosis factor...
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