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Article

Prognostic impact of INK4A deletion in Ewing sarcoma

15 Aug 2000

Abstract excerpt

BACKGROUND: The primary genetic alteration in > 95% of Ewing sarcomas (ES) is a specific fusion of EWS with FLI1 or ERG. Secondary genetic alterations possibly involved in progression of ES are not well understood. A recent study found loss of the negative cell cycle regulator gene INK4A in 8 of 27 ES samples (30%). To confirm these findings and evaluate their prognostic significance, the authors studied INK4A...

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PMID: 10951342
DOI: 10.1002/1097-0142(20000815)89:4<793::aid-cncr11>3.0.co;2-m

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