Article
Activation of the signal transducer gp130 by interleukin-11 and interleukin-6 is mediated by similar molecular interactions.
The Biochemical journal - 1 May 1998
Dahmen H, Horsten U, Küster A, Jacques Y, Minvielle S, Kerr I M, Ciliberto G, Paonessa G, Heinrich P C, Müller-Newen G
Abstract excerpt
The transmembrane glycoprotein gp130 is involved in many cytokine-mediated cellular responses and acts therein as the signal transducing receptor subunit. Interleukin-6 (IL-6) and interleukin-11 (IL-11), in complex with their specific alpha-receptors, homodimerize gp130 and, as a consequence, activate the Janus kinase (Jak)/signal transducer and activator of transcription (STAT) signalling pathway in their target...
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