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Article

Hypermethylation of the prostacyclin synthase (PTGIS) promoter is a frequent event in colorectal cancer and associated with aneuploidy.

Oncogene - 10 Nov 2005

Frigola Jordi, Muñoz Mar, Clark Susan J, Moreno Victor, Capellà Gabriel, Peinado Miguel A

Abstract excerpt

Inactivation of specific tumor suppressor genes by transcriptional silencing associated with hypermethylation of the promoter is a common event in cancer. We have applied the amplification of intermethylated sites (AIMS) technique to a 100 human colorectal cancers and seven cell lines to identify...

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Source

Identifiers

PMID: 16007128
DOI: 10.1038/sj.onc.1208883

Genes

PTGIS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16007128-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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