Article
Microsatellite instability and allelic imbalance in primary and secondary colorectal cancer.
The Australian and New Zealand journal of surgery - 1 Aug 2000
Schneider A, Rohr S, Kelly M D, Mitry R, Pignatelli M, Doré C J, Gaub M P, Jaeck D, Meyer C, Oudet P, Habib N A
Abstract excerpt
BACKGROUND: Several studies of colorectal cancer have shown an association between the number and type of genomic defects and the stage of disease. A subset of colorectal tumours are due to inactivation of DNA mismatch repair genes and these tumours exhibit microsatellite instability. The aim of the present study was to compare and contrast the genomic defects present in both the primary and metastatic stages of...
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