Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human Papillomavirus Type 16 E7 Oncoprotein Binds and Inactivates Growth-Inhibitory Insulin-Like Growth Factor Binding Protein 3

1 Sept 2000

Abstract excerpt

The E7 protein encoded by human papillomavirus type 16 is one of the few viral genes that can immortalize primary human cells and thereby override cellular senescence. While it is generally assumed that this property of E7 depends on its interaction with regulators of the cell cycle, we show here that E7 targets insulin-like growth factor binding protein 3 (IGFBP-3), the product of a p53-inducible gene that is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer, Hypoxia, and Metabolism
Share to Cancer-related Molecular Pathways
Share to Growth Hormone and Insulin-like Growth Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 10938125
DOI: 10.1128/mcb.20.17.6483-6495.2000

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human Papillomavirus Type 16 E7 Oncoprotein Binds and Inactivates Growth-Inhibitory Insulin-Like Growth Factor Binding Protein 3PMID 10938125Read ↗

Human papillomavirus type 16 E7 oncoprotein inhibits apoptosis mediated by nuclear insulin-like growth factor-binding protein-3 by enhancing its ubiquitin/proteasome-dependent degradation.Semantic proximity Read ↗

Immortalization of distinct human mammary epithelial cell types by human papilloma virus 16 E6 or E7.Semantic proximity Read ↗

Loss of p53 protein in human papillomavirus type 16 E6-immortalized human mammary epithelial cellsSemantic proximity Read ↗

14-3-3 proteins are involved in the regulation of mammalian cell proliferation.Semantic proximity Read ↗

Mutant p53 can substitute for human papillomavirus type 16 E6 in immortalization of human keratinocytes but does not have E6-associated trans-activation or transforming activity.Semantic proximity Read ↗

Induction of apoptosis by p53 is independent of its oligomeric state and can be abolished by HPV-18 E6 through ubiquitin mediated degradation.Semantic proximity Read ↗

Human Papillomavirus E7 Repression in Cervical Carcinoma Cells Initiates a Transcriptional Cascade Driven by the Retinoblastoma Family, Resulting in SenescenceSemantic proximity Read ↗

Analysis of the p53-mediated G1 growth arrest pathway in cells expressing the human papillomavirus type 16 E7 oncoproteinSemantic proximity Read ↗

Characterization of a novel positive transcription regulatory element that differentially regulates the insulin-like growth factor binding protein-3 (IGFBP-3) gene in senescent cells.Semantic proximity Read ↗

YPEL3, a p53-Regulated Gene that Induces Cellular SenescenceSemantic proximity Read ↗

Downregulation of 14-3-3sigma prevents clonal evolution and leads to immortalization of primary human keratinocytes.Semantic proximity Read ↗

Apoptosis resistance of senescent human fibroblasts is correlated with the absence of nuclear IGFBP‐3Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.