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Article

Apoptosis resistance of senescent human fibroblasts is correlated with the absence of nuclear IGFBP‐3

21 Nov 2005

Abstract excerpt

Signaling through the insulin/IGF axis plays a major role in determining the rate of aging in many species. IGF-binding proteins (IGFBPs) modulate the IGF pathway in higher organisms. IGFBP-3 accumulates in conditioned medium of senescent human fibroblasts, suggesting that it may contribute to the senescent phenotype. IGFBP-3 can enhance apoptotic cell death in tumor cells due to its ability to target...

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PMID: 16300485
DOI: 10.1111/j.1474-9726.2005.00180.x

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