Article
Human papillomavirus type 16 E7 oncoprotein inhibits apoptosis mediated by nuclear insulin-like growth factor-binding protein-3 by enhancing its ubiquitin/proteasome-dependent degradation.
Carcinogenesis - 1 Dec 2007
Santer Frédéric R, Moser Barbara, Spoden Gilles A, Jansen-Dürr Pidder, Zwerschke Werner
Abstract excerpt
The E7 protein encoded by the oncogenic human papillomavirus type 16 has been shown to bind and inactivate insulin-like growth factor-binding protein-3 (IGFBP-3), the pro-apoptotic product of a tumour suppressor gene; however, the molecular mechanism underlying E7-induced inactivation of IGFBP-3...
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