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Article

The Otx2 Homeoprotein Regulates Expression from the Gonadotropin-Releasing Hormone Proximal Promoter

1 Aug 2000

Abstract excerpt

The GnRH gene is expressed exclusively in a highly restricted population of approximately 800 neurons in the mediobasal hypothalamus in the mouse. The Otx2 homeoprotein has been shown to colocalize with GnRH in embryonic mouse brain. We have identified a highly conserved bicoid-related Otx target sequence within the proximal promoter region of the GnRH gene from several species. This element from the rat GnRH...

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Identifiers

PMID: 10935548
DOI: 10.1210/mend.14.8.0509

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Source receipt: pubmed, retrieved 7 Sept 2026.

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The Otx2 Homeoprotein Regulates Expression from the Gonadotropin-Releasing Hormone Proximal PromoterPMID 10935548Read ↗

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