Article
Gelatinase B is required for alveolar bronchiolization after intratracheal bleomycin.
The American journal of pathology - 1 Aug 2000
Betsuyaku T, Fukuda Y, Parks W C, Shipley J M, Senior R M
Abstract excerpt
Increased expression of matrix metalloproteinases, particularly gelatinase B (MMP-9), has been described in the lungs in pulmonary fibrosis. Intratracheal bleomycin is often used experimentally to produce lesions resembling human fibrosing alveolitis. To assess the role of gelatinase B in bleomycin-induced fibrosing alveolitis, we instilled bleomycin intratracheally into gelatinase B-deficient mice and gelatinase...
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