Article
Vesicular stomatitis virus transcription inhibited by purified MxA protein.
Virology - 10 Jan 1995
Schwemmle M, Weining K C, Richter M F, Schumacher B, Staeheli P
Abstract excerpt
MxA is a GTPase encoded by an interferon-inducible human gene. Its constitutive expression renders transfected mammalian cells resistant to infections with several different RNA viruses, including vesicular stomatitis virus (VSV). Differences in viral RNA levels of VSV-infected cells either expressing or lacking MxA indicated that VSV mRNA synthesis is the principal target of MxA action. We now used purified...
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