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Interferon-induced human MxA GTPase blocks nuclear import of Thogoto virus nucleocapsids

2 Mar 1999

Abstract excerpt

Interferon-induced human MxA protein belongs to the dynamin superfamily of large GTPases. It exhibits antiviral activity against a variety of RNA viruses, including Thogoto virus, an influenza virus-like orthomyxovirus transmitted by ticks. Here, we report that MxA blocks the transport of Thogoto virus nucleocapsids into the nucleus, thereby preventing transcription of the viral genome. This interaction can be...

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PMID: 10051598
DOI: 10.1073/pnas.96.5.2082

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