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Article

Zinc-binding site of human immunodeficiency virus 2 Vpx prevents instability and dysfunction of the protein.

The Journal of general virology - 1 Feb 2017

Yamamoto Minami, Koga Ryoko, Fujino Haruna, Shimagaki Kazunori, Ciftci Halil Ibrahim, Kamo Masahiro, Tateishi Hiroshi, Otsuka Masami, Fujita Mikako

Abstract excerpt

Human immunodeficiency virus 2 Vpx coordinates zinc through residues H39, H82, C87 and C89. We reported previously that H39, H82 and C87 mutants maintain Vpx activity to facilitate the degradation of SAMHD1. Herein, the expression of Vpx mutants in cells was examined in detail. We demonstrated that the zinc-binding site stabilizes the protein to keep its function in virus growth when low levels of Vpx are...

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Source

Identifiers

PMID: 28284276
DOI: 10.1099/jgv.0.000701

Genes

SAMHD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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