Article
A mutation in RYK is a genetic factor for nonsyndromic cleft lip and palate.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association - 1 May 2006
Watanabe Akira, Akita Sadanori, Tin Nguyen Thi Duc, Natsume Nagato, Nakano Yoko, Niikawa Norio, Uchiyama Takeshi, Yoshiura Koh-ichiro
Abstract excerpt
OBJECTIVE: The RYK, EPHB2, and EPHB3 genes are attractive candidates for cleft lip and/or palate and cleft palate only pathogenesis. Both the Ryk-deficient mouse and Ephb2/Ephb3 (genes for interaction molecules with RYK) double-mutant mouse show cleft palate. SETTING: Mutation searches for RYK, EPHB2, and EPHB3 were carried out in a large number of Japanese and Vietnamese patients with cleft lip and/or palate and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.