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Article

Small-molecule Wnt agonists correct cleft palates in Pax9 mutant mice in utero.

Development (Cambridge, England) - 15 Oct 2017

Jia Shihai, Zhou Jing, Fanelli Christopher, Wee Yinshen, Bonds John, Schneider Pascal, Mues Gabriele, D'Souza Rena N

Abstract excerpt

Clefts of the palate and/or lip are among the most common human craniofacial malformations and involve multiple genetic and environmental factors. Defects can only be corrected surgically and require complex life-long treatments. Our studies utilized the well-characterized Pax9-/- mouse model with a consistent cleft palate phenotype to test small-molecule Wnt agonist therapies. We show that the absence of Pax9...

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Identifiers

PMID: 28893947
DOI: 10.1242/dev.157750
PMCID: PMC5675451

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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