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Article

Increased reactive oxygen species in familial amyotrophic lateral sclerosis with mutations in SOD1.

Journal of the neurological sciences - 15 Jun 2000

Said Ahmed M, Hung W Y, Zu J S, Hockberger P, Siddique T

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a paralytic disorder characterized by degeneration of large motor neurons of the brain and spinal cord. A subset of ALS is inherited (familial ALS, FALS) and is associated with more than 70 different mutations in the SOD1 gene. Here we report that lymphoblast cell lines derived from FALS patients with 16 different mutations in SOD1 gene exhibit significant increase of...

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Source

Identifiers

PMID: 10930589
DOI: 10.1016/s0022-510x(00)00317-8

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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