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Article

Redox profiles of amyotrophic lateral sclerosis lymphoblasts with or without known SOD1 mutations.

European journal of clinical investigation - 1 Sept 2022

Cunha-Oliveira Teresa, Silva Daniela Franco, Segura Luis, Baldeiras Inês, Marques Ricardo, Rosenstock Tatiana, Oliveira Paulo J, Silva Filomena S G

Abstract excerpt

BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a fatal and rapidly progressing neurodegenerative disease that affects motor neurons. This disease is associated with oxidative stress especially in mutant superoxide dismutase 1 (mutSOD1) patients. However, less is known for the most prevalent sporadic ALS form, due to a lack of disease models. Here, we studied oxidative stress profiles in lymphoblasts from ALS...

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PMID: 35467758
DOI: 10.1111/eci.13798

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