Article
A locus for an autosomal dominant form of progressive renal failure and hypertension at chromosome 1q21.
American journal of human genetics - 1 Sept 2000
Cohn D H, Shohat T, Yahav M, Ilan T, Rechavi G, King L, Shohat M
Abstract excerpt
Linkage studies were performed in a large family with an autosomal dominant phenotype characterized by nephropathy and hypertension. In this family of Iraqi Jewish origin, the nephropathy develops into progressive renal failure. By performing a genomewide linkage search, we localized the disease gene to chromosome 1q21; the highest LOD score was obtained for the marker at locus D1S305, which yielded a maximum LOD...
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