Article
Induction of Th1 response by dendritic cells pulsed with autologous melanoma apoptotic bodies.
Anticancer research - 1 Jan 2000
Chang J W, Peng M, Vaquerano J E, Zhou Y M, Clinton R A, Hyun W C, Giedlin M A, Leong S P
Abstract excerpt
BACKGROUND: We hypothesize that dendritic cells (DCs) can process antigens from autologous melanoma apoptotic bodies (MABs) and induce effector T cells in melanoma patients. MATERIALS AND METHODS: Peripheral blood mononuclear cells were obtained from three stage IV melanoma patients and adherent cells were cultured in complete medium (CM) containing GM-CSF (800 U/ml) and IL-4 (1000 U/ml) for 7 days. Autologous...
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