Article
Helicobacter pylori urease binds to class II MHC on gastric epithelial cells and induces their apoptosis.
Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 2000
Fan X, Gunasena H, Cheng Z, Espejo R, Crowe S E, Ernst P B, Reyes V E
Abstract excerpt
Infection by Helicobacter pylori leads to injury of the gastric epithelium and a cellular infiltrate that includes CD4+ T cells. H. pylori binds to class II MHC molecules on gastric epithelial cells and induces their apoptosis. Because urease is an abundant protein expressed by H. pylori, we examined whether it had the ability to bind class II MHC and induce apoptosis in class II MHC-bearing cells. Flow cytometry...
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