Article
Induction of a Th17 cell response by Helicobacter pylori Urease subunit B.
Immunobiology - 1 Jul 2011
Zhang Jin-Yu, Liu Tao, Guo Hong, Liu Xiao-Fei, Zhuang Yuan, Yu Shu, Chen Li, Wu Chao, Zhao Zhuo, Tang Bin, Luo Ping, Mao Xu-Hu, Guo Gang, Shi Yun, Zou Quan-Ming
Abstract excerpt
Th17 cells represent a novel subset of CD4(+) T cells, which is associated with Helicobacter pylori infection. In the present study, we investigated the potential role of Urease subunit B (UreB) in the induction of Th17 cell response. Co-cultured splenic lymphocytes from H. pylori-infected mice with the recombinant UreB (rUreB) elevated IL-17 secretion and caused an increase in the number of Th17 cells. The...
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