Frame-shift mutations in NAD(P)H flavin oxidoreductase encoding gene (<i>frxA</i>) from metronidazole resistant<i>Helicobacter pylori</i>ATCC43504 and its involvement in metronidazole resistance

Abstract excerpt

Metronidazole is a critical ingredient for combination therapies of Helicobacter pylori infection, the major cause of peptic ulcer and gastric cancer. It has been recently reported that metronidazole resistance from H. pylori ATCC43504 is caused by the insertion of a mini-IS605 sequence and deletion of sequences in an oxygen insensitive NAD(P)H nitroreductase encoding gene (rdxA). We also found that an additional...

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