The molecular basis of vancomycin resistance in clinically relevant <i>Enterococci:</i> Crystal structure of <scp>d</scp> -alanyl- <scp>d</scp> -lactate ligase (VanA)

Abstract excerpt

d-alanine-d-lactate ligase from Enterococcus faecium BM4147 is directly responsible for the biosynthesis of alternate cell-wall precursors in bacteria, which are resistant to the glycopeptide antibiotic vancomycin. The crystal structure has been determined with data extending to 2.5-A resolution. This structure shows that the active site has unexpected interactions and is distinct from previous models for...

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