Article
Active-site mutants of the VanC2 D-alanyl-D-serine ligase, characteristic of one vancomycin-resistant bacterial phenotype, revert towards wild-type D-alanyl-D-alanine ligases.
Chemistry & biology - 1 Apr 1998
Healy V L, Park I S, Walsh C T
Abstract excerpt
BACKGROUND: The rising number of vancomycin-resistant enterococci (VREs) is a major concern to modern medicine because vancomycin is currently the 'last resort' drug for life-threatening infections. The D-alanyl-D-X ligases (where X is an hydroxy or amino acid) of bacteria catalyze a critical ste...
Topics
- Amino Acid Sequence
- Anti-Bacterial Agents
- Bacterial Proteins
- Drug Resistance, Microbial
- Enterococcus
- Ligases
- Membrane Proteins
- Models, Molecular
- Molecular Sequence Data
- Peptide Synthases
- Phenotype
- Phylogeny
- Point Mutation
- Sequence Alignment
- Sequence Homology, Amino Acid
- Transformation, Bacterial
- Vancomycin