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Article

Sequencing of the ddl gene and modeling of the mutated D-alanine:D-alanine ligase in glycopeptide-dependent strains of Enterococcus faecium.

Protein science : a publication of the Protein Society - 1 Apr 2001

Gholizadeh Y, Prevost M, Van Bambeke F, Casadewall B, Tulkens P M, Courvalin P

Abstract excerpt

Glycopeptide dependence for growth in enterococci results from mutations in the ddl gene that inactivate the host D-Ala:D-Ala ligase. The strains require glycopeptides as inducers for synthesis of resistance proteins, which allows for the production of peptidoglycan precursors ending in D-Ala-D-Lac instead of D-Ala-D-Ala. The sequences of the ddl gene from nine glycopeptide-dependent Enterococcus faecium clinical...

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Identifiers

PMID: 11274474
DOI: 10.1110/ps.39101
PMCID: PMC2373979

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Sequencing of the ddl gene and modeling of the mutated D-alanine:D-alanine ligase in glycopeptide-dependent strains of Enterococcus faecium.PMID 11274474Read ↗

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