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Article

Structural and functional characterization of VanG D-Ala:D-Ser ligase associated with vancomycin resistance in Enterococcus faecalis.

The Journal of biological chemistry - 2 Nov 2012

Meziane-Cherif Djalal, Saul Frederick A, Haouz Ahmed, Courvalin Patrice

Abstract excerpt

d-Alanyl:d-lactate (d-Ala:d-Lac) and d-alanyl:d-serine ligases are key enzymes in vancomycin resistance of Gram-positive cocci. They catalyze a critical step in the synthesis of modified peptidoglycan precursors that are low binding affinity targets for vancomycin. The structure of the d-Ala:d-Lac ligase VanA led to the understanding of the molecular basis for its specificity, but that of d-Ala:d-Ser ligases had...

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Identifiers

PMID: 22969085
DOI: 10.1074/jbc.M112.405522
PMCID: PMC3488035

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Structural and functional characterization of VanG D-Ala:D-Ser ligase associated with vancomycin resistance in Enterococcus faecalis.PMID 22969085Read ↗

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