Article
D-Alanyl-D-lactate and D-alanyl-D-alanine synthesis by D-alanyl-D-alanine ligase from vancomycin-resistant Leuconostoc mesenteroides. Effects of a phenylalanine 261 to tyrosine mutation.
The Journal of biological chemistry - 4 Apr 1997
Park I S, Walsh C T
Abstract excerpt
The Gram-positive bacterium Leuconostoc mesenteroides, ATCC 8293, is intrinsically resistant to the antibiotic vancomycin. This phenotype correlates with substitution of D-Ala-D-lactate (D-Ala-D-Lac) termini for D-Ala-D-Ala termini in peptidoglycan intermediates in which the depsipeptide has much...
Topics
- Alanine
- Amino Acid Sequence
- Binding Sites
- Dipeptides
- Drug Resistance, Microbial
- Lactates
- Leuconostoc
- Models, Molecular
- Molecular Sequence Data
- Peptide Synthases
- Phenotype
- Phenylalanine
- Point Mutation
- Sequence Alignment
- Tyrosine
- Vancomycin