Article
Reduced voltage sensitivity of activation of P/Q-type Ca2+ channels is associated with the ataxic mouse mutation rolling Nagoya (tg(rol)).
The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Aug 2000
Mori Y, Wakamori M, Oda S, Fletcher C F, Sekiguchi N, Mori E, Copeland N G, Jenkins N A, Matsushita K, Matsuyama Z, Imoto K
Abstract excerpt
Recent genetic analyses have revealed an important association of the gene encoding the P/Q-type voltage-dependent Ca(2+) channel alpha(1A) subunit with hereditary neurological disorders. We have identified the ataxic mouse mutation, rolling Nagoya (tg(rol)), in the alpha(1A) gene that leads to a charge-neutralizing arginine-to-glycine substitution at position 1262 in the voltage sensor-forming segment S4 in...
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