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Article

Spinocerebellar ataxia type 6 mutation alters P-type calcium channel function.

The Journal of biological chemistry - 14 Apr 2000

Toru S, Murakoshi T, Ishikawa K, Saegusa H, Fujigasaki H, Uchihara T, Nagayama S, Osanai M, Mizusawa H, Tanabe T

Abstract excerpt

Abnormal CAG repeat expansion in the alpha1A voltage-dependent calcium channel gene is associated with spinocerebellar ataxia type 6, an autosomal dominant cerebellar ataxia with a predominant loss of the Purkinje cell. A reverse transcriptase-polymerase chain reaction analysis of mRNA from mouse Purkinje cells revealed a predominant expression of the alpha1A channel lacking an asparagine-proline (NP) stretch in...

Topics

Animals
Base Sequence
Calcium Channels, P-Type
Calcium Channels, Q-Type
Cells, Cultured
Humans
Male
Mice
Mice, Inbred C57BL
Molecular Sequence Data
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Peptides

Rabbits

Reverse Transcriptase Polymerase Chain Reaction

Spinocerebellar Degenerations

Source

Identifiers

PMID: 10753886
DOI: 10.1074/jbc.275.15.10893

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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