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Energy status and HIF signalling in chorionic villi show no evidence of hypoxic stress during human early placental development

11 Nov 2014

Abstract excerpt

Early human placental and embryonic development occurs in a physiologically low oxygen environment supported by histiotrophic secretions from endometrial glands. In this study, we compare the placental metabolomic profile in the first, second and third trimesters to determine whether the energy demands are adequately met in the first trimester. We investigated whether hypoxia-inducible factors, HIF-1α and/or...

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PMID: 25391298
DOI: 10.1093/molehr/gau105

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