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Article

Genotyping and site-directed mutagenesis of a cytochrome P450 meander Pro-X-Arg motif critical to CYP4B1 catalysis.

Toxicology and applied pharmacology - 15 Jan 2003

Zheng Yi-Min, Henne Kirk R, Charmley Patrick, Kim Richard B, McCarver D Gail, Cabacungan Erwin T, Hines Ronald N, Rettie Allan E

Abstract excerpt

CYP4B1 isoforms from rodents and other common laboratory animals are involved in the bioactivation of a range of protoxins, including 2-aminofluorene, 4-ipomeanol, and valproic acid. However, an earlier study provided evidence for a human allele encoding a nonfunctional CYP4B1 enzyme due to a Pro427Ser transversion in the meander region of the protein. In the present study, the CYP4B1 gene from several racial...

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PMID: 12639503
DOI: 10.1016/s0041-008x(02)00028-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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