Article
Association study of the tryptophan hydroxylase gene and bipolar affective disorder using family-based internal controls.
American journal of medical genetics - 12 Jun 2000
Rietschel M, Schorr A, Albus M, Franzek E, Kreiner R, Held T, Knapp M, Müller D J, Schulze T G, Propping P, Maier W, Nöthen M M
Abstract excerpt
The tryptophan hydroxylase (TPH) gene encodes for the rate-limiting enzyme of the serotonin metabolism and, therefore, has to be considered a major candidate for association studies in affective disorders. Recently, an association between this gene and bipolar affective disorder has been reported in a French population. We sought to replicate this finding in a German sample. Allele frequencies of a biallelic...
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