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Article

Western Hunter-Gatherer genetic ancestry contributes to human longevity in the Italian population.

GeroScience - 1 Oct 2026

Sarno Stefania, Iannuzzi Vincenzo, Sazzini Marco, Pirazzini Chiara, Bacalini Maria Giulia, Gentilini Davide, Passarino Giuseppe, Mari Daniela, Monti Daniela, Nacmias Benedetta, Sorbi Sandro, Pettener Davide, Luiselli Donata, Franceschi Claudio, Garagnani Paolo, Giuliani Cristina

Abstract excerpt

The genetics of human longevity has been primarily studied using classical methods developed in genome-wide association studies. With the recent advances in paleogenomics, it is now possible to investigate to what extent ancient population ancestries contribute to complex traits. In this study, we explored the role of ancient genetic components in human longevity by focusing on the Italian Peninsula, whose...

Read the complete abstract on PubMed

Topics

Aged, 80 and over
Female
Humans
Male
European People

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Genome-Wide Association Study

Italy

Longevity

Polymorphism, Single Nucleotide

White People

Centenarians

Source

Open in PubMed Open full text

Identifiers

PMID: 41389162
DOI: 10.1007/s11357-025-02043-4
PMCID: PMC13601382

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 20 Oct 2026.

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