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Article

Identification, evolution, and essentiality of the mevalonate pathway for isopentenyl diphosphate biosynthesis in gram-positive cocci.

Journal of bacteriology - 1 Aug 2000

Wilding E I, Brown J R, Bryant A P, Chalker A F, Holmes D J, Ingraham K A, Iordanescu S, So C Y, Rosenberg M, Gwynn M N

Abstract excerpt

The mevalonate pathway and the glyceraldehyde 3-phosphate (GAP)-pyruvate pathway are alternative routes for the biosynthesis of the central isoprenoid precursor, isopentenyl diphosphate. Genomic analysis revealed that the staphylococci, streptococci, and enterococci possess genes predicted to encode all of the enzymes of the mevalonate pathway and not the GAP-pyruvate pathway, unlike Bacillus subtilis and most...

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Identifiers

PMID: 10894743
DOI: 10.1128/JB.182.15.4319-4327.2000
PMCID: PMC101949

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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