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Article

A redundant isoprenoid biosynthetic pathway supports Staphylococcus aureus metabolic versatility.

mBio - 13 Aug 2025

Burtchett Troy A, Ottosen Elizabeth N, Jitsukawa Tomotaka, Kaneko Momoko, Yasui Miu, Lysne Jessica A, Kies Paige J, Bailey Jessica A, Thomas Sean M, Fujisaki Shingo, Hammer Neal D

Abstract excerpt

Isoprenoids are ubiquitous molecules that serve as fundamental building blocks for life. In bacteria, isoprenoids are precursors for carotenoid pigments, respiratory cofactors, and essential sugar carrier lipids, such as lipid II. Isoprenoid synthesis initiates via condensation of the five-carbon (C5) precursors, isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). This initial reaction condenses...

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Biosynthetic Pathways
Hemiterpenes
Organophosphorus Compounds
Polyisoprenyl Phosphates
Sesquiterpenes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Staphylococcal Infections

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Open in PubMed Open full text

Identifiers

PMID: 40586551
DOI: 10.1128/mbio.00353-25
PMCID: PMC12345219

Genes

IPP
C5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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