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Article

Expression, purification, characteristics and homology modeling of the HMGS from Streptococcus pneumoniae.

Biomedical and environmental sciences : BES - 1 Jun 2009

Ben Ya-Li, Cui Gu-Zhen, Li Chen, Han Rui, Zhang Jie, Zhang Qing-Ye, Wan Jian, Liu De-Li

Abstract excerpt

OBJECTIVE: To understand the molecular basis for a potential reaction mechanism and develop novel antibiotics with homology modeling for 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase (HMGS). METHODS: The genetic engineering technology and the composer module of SYBYL7.0 program were used, while the HMGS three-dimensional structure was analyzed by homology modeling. RESULTS: The mvaS gene was cloned...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19725466
DOI: 10.1016/S0895-3988(09)60050-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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