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Article

Mutations in Escherichia coli aceE and ribB genes allow survival of strains defective in the first step of the isoprenoid biosynthesis pathway.

PloS one - 1 Jan 2012

Perez-Gil Jordi, Uros Eva Maria, Sauret-Güeto Susanna, Lois L Maria, Kirby James, Nishimoto Minobu, Baidoo Edward E K, Keasling Jay D, Boronat Albert, Rodriguez-Concepcion Manuel

Abstract excerpt

A functional 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway is required for isoprenoid biosynthesis and hence survival in Escherichia coli and most other bacteria. In the first two steps of the pathway, MEP is produced from the central metabolic intermediates pyruvate and glyceraldehyde 3-phosphate via 1-deoxy-D-xylulose 5-phosphate (DXP) by the activity of the enzymes DXP synthase (DXS) and DXP...

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PMID: 22928031
DOI: 10.1371/journal.pone.0043775
PMCID: PMC3424233

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