Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ligand-dependent transcriptional enhancement by DNA curvature between two half motifs of the estrogen response element in the human estrogen receptor alpha gene.

Gene - 10 Jul 2002

Li Xiao-man, Onishi Yoshiaki, Kuwabara Kentaro, Rho Jeung-yon, Wada-Kiyama Yuko, Sakuma Yasuo, Kiyama Ryoiti

Abstract excerpt

We previously reported five DNA bend sites (ERB-4 to -1, and ERB+1) in the promoter region of the human estrogen receptor alpha (ERalpha) gene [FEBS Lett. 444 (1999) 117]. One of these sites, ERB-2, was accompanied by two half motifs of the estrogen response element (ERE) and several short poly(dA)(.)poly(dT) tracts including an A(4) tract located next to a half ERE motif. This A(4) tract and the 20 bp immediate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Binding, Competitive
Share to Estrogen Receptor alpha

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Estrogens

Share to Nucleic Acid Conformation

Share to Oligonucleotides

Share to Receptors, Estrogen

Share to Response Elements

Share to Transcriptional Activation

Source

Identifiers

PMID: 12234690
DOI: 10.1016/s0378-1119(02)00803-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ligand-dependent transcriptional enhancement by DNA curvature between two half motifs of the estrogen response element in the human estrogen receptor alpha gene.PMID 12234690Read ↗

Transcriptional activation of transforming growth factor alpha by estradiol: requirement for both a GC-rich site and an estrogen response element half-siteSemantic proximity Read ↗

Regulation of estrogen receptor gene mediated by promoter B responsible for its enhanced expression in human breast cancerSemantic proximity Read ↗

Targeted mutation of key residues at the start of helix 12 in the hERalpha ligand-binding domain identifies the role of hydrogen-bonding and hydrophobic interactions in the activity of the protein.Semantic proximity Read ↗

Cloning and Characterization of Human Estrogen Receptor β PromoterSemantic proximity Read ↗

Transcription Activation by the Human Estrogen Receptor Subtypeβ (ERβ) Studied with ERβ and ERα Receptor Chimeras<sup>1</sup>Semantic proximity Read ↗

Human Prolactin Gene Promoter Regulation by Estrogen: Convergence with Tumor Necrosis Factor-α SignalingSemantic proximity Read ↗

Effects of estradiol and 4-hydroxytamoxifen on the conformation, thermal stability, and DNA recognition of estrogen receptor beta.Semantic proximity Read ↗

Sp1 binding sites and an estrogen response element half-site are involved in regulation of the human progesterone receptor A promoter.Semantic proximity Read ↗

Influence of estrogen and variations at the BRCA1 promoter region on transcription and translation.Semantic proximity Read ↗

Human estrogen receptor (ER) gene promoter-P1: estradiol-independent activity and estradiol inducibility in ER+ and ER- cells.Semantic proximity Read ↗

Estrogen induction of TGF-α is mediated by an estrogen response element composed of two imperfect palindromesSemantic proximity Read ↗

Modulation of estrogen receptor alpha function and stability by tamoxifen and a critical amino acid (Asp-538) in helix 12.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.