Article
Transduction effect of antisense K-ras on malignant phenotypes in gastric cancer cells.
Cancer letters - 31 Aug 2000
Song J J, Lee H, Kim E, Kim Y S, Yoo N C, Roh J K, Kim B S, Kim J
Abstract excerpt
The antitumoral effects of antisense RNA to K-ras were investigated in gastric cancer cell lines by examining the level of K-ras expression and the tumorigenicity in vitro and in vivo. Polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP), DNA sequencing, and immunoblotting analysis revealed that YCC-1 gastric cancer cells overexpressed wild type K-ras, whereas YCC-2 cells had a homozygous...
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