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Article

A mathematical model of caspase function in apoptosis.

Nature biotechnology - 1 Jul 2000

Fussenegger M, Bailey J E, Varner J

Abstract excerpt

Caspases (cysteine-containing aspartate-specific proteases) are at the core of the cell's suicide machinery. These enzymes, once activated, dismantle the cell by selectively cleaving key proteins after aspartate residues. The events culminating in caspase activation are the subject of intense study because of their role in cancer, and neurodegenerative and autoimmune disorders. Here we present a mechanistic...

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Identifiers

PMID: 10888847
DOI: 10.1038/77589

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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