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Article

Phosphatase activity of histidine kinase EnvZ without kinase catalytic domain.

Proceedings of the National Academy of Sciences of the United States of America - 5 Jul 2000

Zhu Y, Qin L, Yoshida T, Inouye M

Abstract excerpt

Most histidine kinases are bifunctional enzymes having both kinase and phosphatase activities. The cytoplasmic kinase domain of EnvZ, a transmembrane histidine kinase functioning as an osmosensor in Escherichia coli, consists of two distinct functional subdomains: domain A [EnvZc(223-289)] and domain B [EnvZc(290-450)]. NMR studies demonstrated that domain A consists of a four-helix bundle serving as a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 10884412
DOI: 10.1073/pnas.97.14.7808
PMCID: PMC16626

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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