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Article

The role of the G2 box, a conserved motif in the histidine kinase superfamily, in modulating the function of EnvZ.

Molecular microbiology - 1 Aug 2002

Zhu Yan, Inouye Masayori

Abstract excerpt

Histidine kinase EnvZ, a transmembrane osmotic sensor for Escherichia coli, is a bifunctional enzyme having OmpR (its cognate response regulator) kinase and phosphorylated OmpR (OmpR-P) phosphatase activities. Its cytoplasmic domain consists of domain A responsible for dimerization of EnvZ, histidine phosphotransfer and phosphatase activities, and domain B responsible for ATP binding. Here, we have constructed a...

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Source

Identifiers

PMID: 12139613
DOI: 10.1046/j.1365-2958.2002.03061.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The role of the G2 box, a conserved motif in the histidine kinase superfamily, in modulating the function of EnvZ.PMID 12139613Read ↗

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Mutations that alter the kinase and phosphatase activities of the two-component sensor EnvZ.Semantic proximity Read ↗

Cysteine-scanning analysis of the dimerization domain of EnvZ, an osmosensing histidine kinase.Semantic proximity Read ↗

Phosphatase activity of histidine kinase EnvZ without kinase catalytic domain.Semantic proximity Read ↗

Analysis of the role of the EnvZ linker region in signal transduction using a chimeric Tar/EnvZ receptor protein, Tez1.Semantic proximity Read ↗

A single amino acid substitution in the C terminus of OmpR alters DNA recognition and phosphorylation.Semantic proximity Read ↗

Signal transduction and osmoregulation in Escherichia coli: a novel mutant of the positive regulator, OmpR, that functions in a phosphorylation-independent manner.Semantic proximity Read ↗

The inner membrane histidine kinase EnvZ senses osmolality via helix-coil transitions in the cytoplasm.Semantic proximity Read ↗

Re-examination of the role of the periplasmic domain of EnvZ in sensing of osmolarity signals in Escherichia coli.Semantic proximity Read ↗

A novel sensor-regulator protein that belongs to the homologous family of signal-transduction proteins involved in adaptive responses in Escherichia coli.Semantic proximity Read ↗

Transmembrane signal transduction and osmoregulation in Escherichia coli: I. Analysis by site-directed mutagenesis of the amino acid residues involved in phosphotransfer between the two regulatory components, EnvZ and OmpR.Semantic proximity Read ↗

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