Article
Chelation of intracellular zinc triggers apoptosis in mature thymocytes.
Laboratory investigation; a journal of technical methods and pathology - 1 Jul 1993
McCabe M J, Jiang S A, Orrenius S
Abstract excerpt
BACKGROUND: Thymocyte apoptosis has been shown to be regulated by intracellular levels of cations. Elevation of [Ca2+]i can induce cell death by apoptosis, whereas, Zn2+ prevents it. EXPERIMENTAL DESIGN: A membrane permeable metal ion chelator, N,N,N'N',-tetrakis (2-pyridylmethyl)ethylenediamine (TPEN), was used to examine the role of intracellular zinc in thymocyte (rat and human) apoptosis. Characteristics of...
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