Article
Molecular basis for differing antineurogenic effects of GATA-1a and GATA-1b in Xenopus.
Biochemical and biophysical research communications - 5 Jul 2000
Chen H D, Huang Y K, Ault K, Wong G W, Lin M C, Chen H C, Kung H F
Abstract excerpt
The erythroid transcription factor GATA-1 in Xenopus has been cloned as a pair of presumably duplicated genes designated as xGATA-1a and xGATA-1b. Although both xGATA-1a and xGATA-1b are able to stimulate erythropoiesis, only xGATA-1b is capable of inhibiting neurogenesis in Xenopus embryos. Chimeras of these two genes were constructed by permuting coding and untranslated regions (UTR) on both ends of these two...
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