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Article

In Vivo Evidence of Angiogenesis Induced by Transcription Factor Ets-1

8 Jun 2004

Abstract excerpt

BACKGROUND: A transcription factor, ets-1, regulates the transcription of metalloproteinase genes, the activity of which is necessary for matrix degradation and the migration of endothelial cells. However, no study has demonstrated that ets-1 itself has an angiogenic action in vivo. Thus, we examined (1) the effects of overexpression of the ets-1 gene on angiogenesis in a rat hindlimb ischemia model, and (2) how...

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Identifiers

PMID: 15173033
DOI: 10.1161/01.cir.0000130643.41587.db

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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