Article
TP53 deletions but not trisomy 12 are adverse in B-cell lymphoproliferative disorders.
Cancer genetics and cytogenetics - 1 Jun 2000
Shaw G R, Kronberger D L
Abstract excerpt
Abnormalities of the TP53 tumor suppressor gene at 17p13.1 are prognostically adverse in a variety of hematolymphoid malignancies. The present study utilized interphase fluorescence in situ hybridization (I-FISH) to detect TP53 deletions and trisomy 12 in 101 clinical specimens from 98 patients with B-cell lymphoproliferative disorders (B-LPDs). Twelve patients had TP53 deletions (group A), 23 had trisomy 12...
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