Article
Monte Carlo tests for associations between disease and alleles at highly polymorphic loci.
Annals of human genetics - 1 Jan 1995
Sham P C, Curtis D
Abstract excerpt
In an association analysis comparing cases and controls with respect to allele frequencies at a highly polymorphic locus, a potential problem is that the conventional chi-squared test may not be valid for a large, sparse contingency table. However, reliance on statistics with known asymptotic distribution is now unnecessary, as Monte Carlo simulations can be performed to estimate the significance level of any...
Topics
- Alleles
- Case-Control Studies
- Chi-Square Distribution
- Genetic Markers
- Genetic Predisposition to Disease
- Haplotypes
- Humans
- Monte Carlo Method
- Polymorphism, Genetic